وو تينغياو
In mid-2020, the research teams of Delta University for Science & Technology and Ain Shams University in Egypt joined in publishing reports in “Drug Design, Development and Therapy” and “Oxidative Medicine and Cellular Longevity” proving thatالجانوديرماواضح (also called Lingzhi or Reishi mushroom) can greatly reduce liver and kidney injury caused by cisplatin through the triple effects of anti-oxidation, anti-inflammation and anti-apoptosis.
Following the “Part 1غانوديرما لوكيدوم protects the liver vs. cisplatin hepatotoxicity” of the previous article, the author will introduce how muchغانوديرما لوكيدوم‘s kidney-protecting effect can resist the nephrotoxicity caused by cisplatin in this article in the hope that the data and evidence based on science will bring more confidence to friends who seek to reduce the side effects of chemotherapy.
Part 2غانوديرما لوكيدومprotects the kidney vs. Cisplatin nephrotoxicity
Like the animal experiment on “غانوديرما لوكيدوم protects the liver vs. Cisplatin hepatotoxicity”, healthy rats are divided into 6 groups for a 10-day experiment on ”غانوديرما لوكيدوم protects the kidney vs. Cisplatin nephrotoxicity”:
◆Control Group (Cont): the group that does not receive any treatment;
◆غانوديرما لوكيدوم Group(GL): the group that are not injected with cisplatin but eatsغانوديرما لوكيدوم every day;
◆Cisplatin Group (CP): the group that is only injected with cisplatin but does not eatغانوديرما لوكيدوم;
◆Everyday Group (Daily): the group that is injected with cisplatin and eatsغانوديرما لوسيدوم every day;
◆Every Other Day Group (EOD): the group that is injected with cisplatin and eatsغانوديرما لوسيدوم every other day;
◆Intraperitoneal Group (i.p): the group that is injected cisplatin and receives intraperitoneal injection ofغانوديرما لوكيدوم.
All those who received cisplatin were injected intraperitoneally with 12 mg/kg of Cisplatin on the third day of the experiment to trigger acute kidney injury; those who received the intraperitoneal injection ofغانوديرما لوكيدوم were injected once on the second and sixth days of the experiment. For the groups that ateGanoderma lucidum, whether they ate it every day or every other day, it was calculated from the first day of the experiment.
بعبارة أخرى, in this experimental design, all groups receiving cisplatin andغانوديرما لوكيدوم were givenغانوديرما لوكيدوم before the cisplatin injection. This is slightly different from the animal experiment on “غانوديرما لوكيدوم protects the liver vs. Cisplatin hepatotoxicity” in which cisplatin was given on the first day of the experiment (Cisplatin andغانوديرما لوكيدوم are used together from the beginning, or cisplatin was given first and thenغانوديرما لوكيدوم).
الغانوديرما لوكيدوم material used in this experiment is the same as theغانوديرما لوكيدوم material used in the animal experiment on “غانوديرما لوكيدومprotects the liver vs. Cisplatin hepatotoxicity”. They all contain triterpenes, sterols, السكريات, polyphenols and flavonoids. The dose ofغانوديرما لوكيدوم given, whether orally or by injection, يكون 500 mg/kg per day.
(1) Ganoderma lucidum reduces kidney tissue injury
After the 10-day experiment, blood was drawn to detect the creatinine and blood urea nitrogen content of rats in each group. The results found that cisplatin increased these two indexes sharply, which means that the kidney tissue was seriously injured; لوغانوديرما لوكيدوم is used at the same time, the increase of these two indicators will be much reduced, especially eatingغانوديرما لوكيدوم every day produces a more obvious protective effect (تين.
تين. 1 Effects of Cisplatin andالجانوديرماواضحon Kidney Injury Index
The same results were also reflected in the stained sections of kidney tissues of rats in each group (Fig. 2). When cisplatin causes renal congestion, renal tubule dilatation, and necrosis, shedding, or vacuolar degeneration of renal tubular epithelial cells in rats (there are various arrows indicating injury on the stained section figure), the kidney tissues of the rats of the Everyday Group (Daily) suffered the least injury (there is no arrow representing injuries on the stained section figure).
Since cisplatin accumulates in the epithelial cells of the renal tubules in large quantities, the injury of the renal tubules naturally becomes the main observation target. It can be clearly seen from the quantified degree of renal tubular injury thatغانوديرما لوكيدوم can significantly reduce the renal tubular injury caused by cisplatin. بخاصة, eatingغانوديرما لوكيدوم every day produces the most significant protective effect.
T refers to renal tubules while G refers to glomeruli on the figures of tissue sections; the arrow points to renal congestion, tubular dilatation, نخر, shedding, or vacuolar degeneration of renal tubule epithelial cells due to renal tissue injury.
تين. 2 Effects of Cisplatin andغانوديرما لوكيدوم on kidney tissue
(2) غانوديرما لوكيدوم enhances the anti-oxidative and anti-inflammatory ability of kidney tissue
The damage of cisplatin to kidney tissue is involved in oxidative injury and inflammatory injury. From the oxidation index (H2O2), antioxidant index (SOD), and inflammation index (HMGB-1) measured in the kidney tissues of rats in each group, it can be known that the oxidative injury and inflammatory injury caused by cisplatin can be reduced by the combined use ofغانوديرما لوكيدوم (تين.
3).
تين. 3 Effects of cisplatin andغانوديرما لوكيدوم on the oxidation and inflammation indexes of kidney tissue
(3) غانوديرما لوكيدوم enhances the anti-apoptotic ability of kidney cells
Regardless of whether cisplatin causes kidney cell death through oxidative injury or inflammatory injury, the death mode of kidney cells is “apoptosis.”
في الحقيقة, apoptosis is the body’s normal mechanism to eliminate aging or abnormal cells in order to maintain the quality of life. لذلك, normal tissues and organs can detect apoptotic cells at any time. لكن, when a large number of cells undergo apoptosis due to external factors, the normal operation of tissues and organs will be affected.
تين. 4 shows the apoptosis status of rat kidney tissues in each group. The darker the staining color, the greater the number of apoptosis. Obviously, cisplatin can cause a large number of renal cell apoptosis, but the renal cells protected by Ganoderma lucidum have good resistance to apoptosis caused by cisplatin. When the number of dead kidney cells decreases, the degree of kidney injury is reduced, and kidney function is less affected.
تين. 4 Effects of cisplatin andغانوديرما لوكيدوم on renal cell apoptosis
Only by protecting the liver and kidneys can there be the hope of defeating cancer.
Chemotherapy is the most common and necessary means to treat cancer, but the “double-edged” characteristic of chemotherapy that kills cancer cells and damages normal cells is unbearable for all patients.
Perhaps a strong will can withstand nausea, vomiting, diarrhea, dry mouth, oral ulcers and other discomforts, but the liver and kidneys that metabolize drugs cannot be protected by a strong will.
Once there is no well-functioning liver and kidneys, no matter how thorough the elimination of cancer cells is, it is useless.
The articles, “Lingzhi may ameliorate drug-induced hepatotoxicity” and “Lingzhi may improve drug-induced nephrotoxicity”, through animal experiments, once again answered the reasons why cancer patients receiving adjuvant chemotherapy with Lingzhi are not easily defeated by the toxicity of chemotherapy drugs.
It is hoped that these scientific evidences can convince more patients that they can eatغانوديرما لوكيدوم before, during and after chemotherapy, and they should eat it every day. If they eat enoughغانوديرما لوكيدومevery day, the toxicity of chemotherapy to the liver and kidneys can be mostly resolved byغانوديرما لوكيدوم in the first time.
[مصدر البيانات]
1. Yasmen F Mahran, et al.غانوديرما لوكيدوم Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis. Oxid Med Cell Longev. 2020. دوي: 10.1155/2020/4932587.
2. Hanan M Hassan, وآخرون. Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway byغانوديرما لوكيدوم: Theoretical and Experimental Study. Drug Des Devel Ther. 2020; 14: 2335–2353.
نهاية
نبذة عن الكاتبة/ م. وو تينغياو
Wu Tingyao has been reporting on first-handغانوديرما لوكيدوم information
since 1999. هي مؤلفةالشفاء بالجانوديرما (نشرت في دار النشر الطبية الشعبية في أبريل 2017).
★ يتم نشر هذه المقالة بموجب التفويض الحصري للمؤلف, والملكية تعود إلى GANOHERB
★ لا يمكن إعادة إنتاج الأعمال المذكورة أعلاه, مقتطف أو مستخدم بطرق أخرى دون تصريح من GanoHerb
★ إذا تم ترخيص الأعمال لاستخدامها, ويجب استخدامها ضمن نطاق الترخيص مع الإشارة إلى المصدر: جانوهيرب
★ Violation of the above statement, GanoHerb will pursue its related legal responsibilities
★ تمت كتابة النص الأصلي لهذه المقالة باللغة الصينية بواسطة Wu Tingyao وترجمها إلى الإنجليزية بواسطة Alfred Liu. إذا كان هناك أي اختلاف بين الترجمة (English) والأصل (الصينية), يجب أن تسود الصينية الأصلية. إذا كان لدى القراء أي أسئلة, يرجى الاتصال بالمؤلف الأصلي, آنسة. وو تينغياو.
تمر على الثقافة الصحية لآلاف السنين
المساهمة في العافية للجميع
