يمكن 22, 2015 / جامعة تيانجين للعلوم والتكنولوجيا / Lipids in Health and Disease
نص / وو تينغياو
There have been many scientific discussions on howغانوديرما لوكيدوم fruiting bodies can improve diabetes, but there are few related studies on the role ofغانوديرما لوكيدوم spores in this regard. هذا التقرير, published in “Lipids in Health and Disease” by Tianjin University of Science and Technology, الصين, explores the effect of shell-brokenغانوديرما لوكيدوم مسحوق البوغ(GLSP) with a shell-broken rate >99.9% on blood glucose, blood lipids and oxidative stress in type 2 الفئران المصابة بالسكري.
The three groups of male rats participating in the experiment are all adults, مع 8 rats in each group. مجموعة 1: Normal control, normal rats with ordinary feed; مجموعة 2: Model control, diabetic rats with ordinary feed without intervention; مجموعة 3: GLSP, diabetic rats with ordinary feed, an intervention group utilizing GLSP of 1 g per day by oral gavages for 4 consecutive weeks. In rats, يكتب 2 diabetes results from the destruction of islet cells by injection of Streptozocin.
It was found that the blood glucose of diabetic rats that ate shell-brokenغانوديرما لوكيدوم spore powder began to drop from the second week and was 21% lower than that of diabetic rats that did not take Ganoderma lucidum by the end of the fourth week, but it was still four times the blood glucose of normal rats.
In terms of blood lipid compositions, compared with diabetic rats that did not eat the shell-brokenغانوديرما لوكيدوم مسحوق البوغ, the total cholesterol of diabetic rats in theغانوديرما لوكيدوم group was reduced by 49%, and their triglycerides were reduced by 17.8%. لكن, these indexes of both of them were far away from those of normal rats (their total cholesterol is about five times that of normal rats, and their triglycerides are one and a half times as much.) Only HDL-C, commonly known as “good cholesterol,” rises to levels close to that of normal rats.
Diabetes can significantly increase the oxidative stress in the body, but eating shell-brokenغانوديرما لوكيدوم spores for four weeks can significantly reduce the concentration of MDA (مالونديالدهيد) and ROS (reactive oxygen species) in the blood of diabetic rats. These two values are still higher than those of normal rats, but the two important antioxidant enzymes, GSH-Px (glutathione peroxidase) and SOD (superoxide dismutase) are also higher than those of normal rats, showing that shell-brokenغانوديرما لوكيدوم spores can effectively enhance the antioxidant capacity of diabetic rats, thereby alleviating excessive oxidative stress.
Further analysis revealed that several genes related to lipid metabolism (Acox1, ACC, Insig-1 and Insig-2), as well as genes related to glycogen synthesis (GS2 and GYG1), have more expression levels than those diabetic rats who did not eat shell-brokenغانوديرما لوكيدوم جراثيم. لكن, some genes showed no significant differences, including SREBP-1, Acly, Fas, Fads1, Gpam and Dgat1 involved in lipid metabolism, and PEPCK and G6PC1 involved in carbohydrate metabolism.
All in all, although there is still some distance from “returning to normal”, the shell-brokenغانوديرما لوكيدوم spore powder has shown its benefits for type 2 diabetes within a month, including lowering blood glucose and blood lipids. From the perspective of gene expression, its mechanism of action may be related to promoting glycogen synthesis, inhibiting gluconeogenesis (inhibiting the conversion of non-carbohydrates into glucose), and regulating the proportion of HDL in cholesterol. As for what active ingredients make the shell-brokenغانوديرما لوكيدوم spore powder effective, this paper does not specifically elaborate..
[مصدر] Wang F, وآخرون. Effect of غانوديرما لوكيدوم spores intervention on glucose and lipid metabolism gene expression profiles in type 2 الفئران المصابة بالسكري. Lipids Health Dis. 2015 يمكن 22;14:49. دوي: 10.1186/s12944-015-0045-y.
نهاية
نبذة عن الكاتبة/ م. وو تينغياو
وقد ظل وو تينغ ياو يقدم تقارير عن معلومات الجانوديرما المباشرة منذ ذلك الحين 1999. هي مؤلفةالشفاء بالجانوديرما (نشرت في دار النشر الطبية الشعبية في أبريل 2017).
★ يتم نشر هذه المقالة بموجب التفويض الحصري للمؤلف.
★ لا يمكن إعادة إنتاج الأعمال المذكورة أعلاه, مقتطفة أو مستخدمة بطرق أخرى دون إذن المؤلف.
★ لانتهاكات البيان أعلاه, سوف يتابع المؤلف المسؤوليات القانونية ذات الصلة.
★ تمت كتابة النص الأصلي لهذه المقالة باللغة الصينية بواسطة Wu Tingyao وترجمها إلى الإنجليزية بواسطة Alfred Liu. إذا كان هناك أي اختلاف بين الترجمة (إنجليزي) والأصل (الصينية), يجب أن تسود الصينية الأصلية. إذا كان لدى القراء أي أسئلة, يرجى الاتصال بالمؤلف الأصلي, آنسة. وو تينغياو.
