Peut 22, 2015 / Tianjin University of Science and Technology / Lipids in Health and Disease

Texte/Wu Tingyao

There have been many scientific discussions on howGanoderma lucidum fruiting bodies can improve diabetes, but there are few related studies on the role ofGanoderma lucidum spores in this regard. This report, published in “Lipids in Health and Disease” by Tianjin University of Science and Technology, China, explores the effect of shell-brokenGanoderma lucidum poudre de spores(GLSP) with a shell-broken rate >99.9% on blood glucose, blood lipids and oxidative stress in type 2 diabetic rats.

The three groups of male rats participating in the experiment are all adults, avec 8 rats in each group. Group 1: Normal control, normal rats with ordinary feed; Group 2: Model control, diabetic rats with ordinary feed without intervention; Group 3: GLSP, diabetic rats with ordinary feed, an intervention group utilizing GLSP of 1 g per day by oral gavages for 4 consecutive weeks. In rats, type 2 diabetes results from the destruction of islet cells by injection of Streptozocin.

It was found that the blood glucose of diabetic rats that ate shell-brokenGanoderma lucidum spore powder began to drop from the second week and was 21% lower than that of diabetic rats that did not take Ganoderma lucidum by the end of the fourth week, but it was still four times the blood glucose of normal rats.

In terms of blood lipid compositions, compared with diabetic rats that did not eat the shell-brokenGanoderma lucidum poudre de spores, the total cholesterol of diabetic rats in theGanoderma lucidum group was reduced by 49%, and their triglycerides were reduced by 17.8%. Cependant, these indexes of both of them were far away from those of normal rats (their total cholesterol is about five times that of normal rats, and their triglycerides are one and a half times as much.) Only HDL-C, commonly known as “good cholesterol,” rises to levels close to that of normal rats.

Diabetes can significantly increase the oxidative stress in the body, but eating shell-brokenGanoderma lucidum spores for four weeks can significantly reduce the concentration of MDA (malondialdehyde) and ROS (reactive oxygen species) in the blood of diabetic rats. These two values are still higher than those of normal rats, but the two important antioxidant enzymes, GSH-Px (glutathione peroxidase) and SOD (superoxide dismutase) are also higher than those of normal rats, showing that shell-brokenGanoderma lucidum spores can effectively enhance the antioxidant capacity of diabetic rats, thereby alleviating excessive oxidative stress.

Further analysis revealed that several genes related to lipid metabolism (Acox1, ACC, Insig-1 and Insig-2), as well as genes related to glycogen synthesis (GS2 and GYG1), have more expression levels than those diabetic rats who did not eat shell-brokenGanoderma lucidum spores. Cependant, some genes showed no significant differences, including SREBP-1, Acly, Fas, Fads1, Gpam and Dgat1 involved in lipid metabolism, and PEPCK and G6PC1 involved in carbohydrate metabolism.

All in all, although there is still some distance from “returning to normal”, the shell-brokenGanoderma lucidum spore powder has shown its benefits for type 2 diabetes within a month, including lowering blood glucose and blood lipids. From the perspective of gene expression, its mechanism of action may be related to promoting glycogen synthesis, inhibiting gluconeogenesis (inhibiting the conversion of non-carbohydrates into glucose), and regulating the proportion of HDL in cholesterol. As for what active ingredients make the shell-brokenGanoderma lucidum spore powder effective, this paper does not specifically elaborate..

[Source] Wang F, et autres. Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats. Lipids Health Dis. 2015 Peut 22;14:49. est-ce que je: 10.1186/s12944-015-0045-y.

FIN

À propos de l'auteur/Mme. Wu Tingyao

Wu Tingyao rapporte des informations de première main sur le Ganoderma depuis 1999. Elle est l'auteur deGuérir avec Ganoderma (publié dans The People's Medical Publishing House en avril 2017). 

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★ Le texte original de cet article a été rédigé en chinois par Wu Tingyao et traduit en anglais par Alfred Liu.. S'il y a une divergence entre la traduction (English) et l'original (Chinois), le chinois original prévaudra. Si les lecteurs ont des questions, veuillez contacter l'auteur original, MS. Wu Tingyao.