Wu Tingyao

A tsakiyar 2020, ƙungiyoyin bincike na Jami'ar Delta don Kimiyya da Fasaha da Jami'ar Ain Shams a Masar sun shiga cikin buga rahotanni a cikin "Magungunan Magunguna, Ci gaba da Farfa" da "Magungunan Oxidative da Tsawon Rayuwa" suna tabbatar da hakan.Ganodermalucidum(wanda kuma ake kira Lingzhi ko Reishi naman kaza) na iya rage yawan raunin hanta da koda da cisplatin ke haifarwa ta hanyar sau uku na anti-oxidation, anti-inflammatory da anti-apoptosis.

Biyo bayan “Part 1Ganoderma lucidumyana kare hanta vs. cisplatin hepatotoxicity" na labarin da ya gabata, marubucin zai gabatar da nawaGanoderma lucidumTasirin kare koda zai iya tsayayya da nephrotoxicity da cisplatin ya haifar a cikin wannan labarin a cikin bege cewa bayanai da shaidun da suka danganci kimiyya za su kawo ƙarin tabbaci ga abokai waɗanda ke neman rage tasirin cutar sankara.

Kashi na 2Ganoderma lucidum yana kare koda vs. Cisplatin nephrotoxicity

Kamar gwajin dabba akan "Ganoderma lucidumyana kare hanta vs. Cisplatin hepatotoxicity", an raba berayen lafiya zuwa kungiyoyi 6 don gwaji na kwanaki 10 akan ”Ganoderma lucidumyana kare koda vs. Cisplatin nephrotoxicity":

◆Rukunin Gudanarwa (Ci gaba): ƙungiyar da ba ta samun magani;
◆Ganoderma lucidumRukuni (GL): rukunin da ba a yi musu allurar cisplatin ba amma suna ciGanoderma lucidumkowace rana;
◆Cisplatin Group (CP): rukunin da ake yi wa allurar cisplatin kawai amma ba sa ci.Ganoderma lucidum;
◆Rukunin Kullum (Kullum): rukunin da ake yi wa allurar cisplatin kuma suna ci.Ganoderma Lucidumkowace rana;
◆Kowane Sauran Rana Group (EOD): rukunin da ake yi wa allurar cisplatin kuma suna ci.Ganoderma Lucidumkowace rana;
◆Intraperitoneal Group (ip): kungiyar da aka allurar cisplatin kuma ta karbi allurar intraperitoneal.Ganoderma lucidum.

Duk waɗanda suka karɓi cisplatin an yi musu allura a cikin intraperitoneally tare da 12 mg / kg na Cisplatin a rana ta uku na gwaji don haifar da mummunan rauni na koda;wadanda suka karbi allurar intraperitoneal naGanoderma luciduman yi allurar sau ɗaya a rana ta biyu da ta shida na gwajin.Ga kungiyoyin da suka ci abinciGanoderma lucidum, ko sun ci shi kowace rana ko kowace rana, an ƙididdige shi daga ranar farko ta gwaji.

A wasu kalmomi, a cikin wannan ƙirar gwaji, duk ƙungiyoyi suna karɓar cisplatin daGanoderma luciduman ba suGanoderma lucidumkafin allurar cisplatin.Wannan ya ɗan bambanta da gwajin dabba akan "Ganoderma lucidumyana kare hanta vs. Cisplatin hepatotoxicity” wanda aka ba da cisplatin a ranar farko ta gwaji (Cisplatin daGanoderma lucidumana amfani da su tare tun daga farko, ko kuma an ba da cisplatin da farko sannan kumaGanoderma lucidum).

TheGanoderma lucidumAbubuwan da aka yi amfani da su a cikin wannan gwaji iri ɗaya ne da naGanoderma lucidumkayan da aka yi amfani da su a gwajin dabba akan "Ganoderma lucidumyana kare hanta vs. Cisplatin hepatotoxicity”.Duk sun ƙunshi triterpenes, sterols, polysaccharides, polyphenols da flavonoids.Kashi naGanoderma lucidumda aka ba, ko ta baki ko ta allura, shine 500 mg / kg kowace rana.

(1) Ganoderma lucidum yana rage raunin koda

Bayan gwajin na kwanaki 10, an zana jini don gano creatinine da abun ciki na urea nitrogen na beraye a cikin kowace rukuni.Sakamakon ya gano cewa cisplatin ya karu da waɗannan alamomi guda biyu sosai, wanda ke nufin cewa ƙwayar koda ya sami mummunan rauni;idanGanoderma lucidumana amfani da su a lokaci guda, karuwar waɗannan alamomi guda biyu za su ragu sosai, musamman cin abinciGanoderma lucidumkowace rana tana haifar da ingantaccen sakamako na kariya (Fig.

1).

Hoto 1Tasirin Cisplatin daGanodermalucidum akan Ƙididdigar Rauni na Koda

Hakanan an nuna irin wannan sakamakon a cikin sassan da aka lalata na ƙwayoyin koda na berayen a cikin kowane rukuni (Fig. 2).Lokacin da cisplatin yana haifar da cunkoso na koda, dilatation na renal tubule, da necrosis, zubarwa, ko vacuolar degeneration na renal tubular epithelial Kwayoyin a cikin berayen (akwai kibiyoyi daban-daban da ke nuna rauni a kan adadi mai tabo), ƙwayoyin koda na berayen na Rukunin Kullum Kullum) ya sami rauni mafi ƙanƙanta (babu kibiya da ke wakiltar raunuka akan adadi mai tabo).

Tun da cisplatin ya taru a cikin sel epithelial na tubules na renal da yawa, raunin tubules na koda a zahiri ya zama babban abin dubawa.Ana iya gani a fili daga ƙididdige ƙimar raunin tubular koda wandaGanoderma lucidumna iya rage yawan raunin koda tubular da cisplatin ya haifar.Musamman, cin abinciGanoderma lucidumkowace rana yana samar da sakamako mafi mahimmanci na kariya.

T yana nufin tubules na koda yayin da G yana nufin glomeruli akan adadi na sassan nama;Kibiya tana nuna cunkoso na koda, dilatation tubular, necrosis, zubarwa, ko ɓarnawar ɓarna na ƙwayoyin epithelial na koda saboda raunin nama na koda.

Hoto.2 Tasirin Cisplatin daGanoderma lucidumakan ƙwayar koda

(2)Ganoderma lucidumyana haɓaka ƙarfin anti-oxidative da anti-mai kumburi na ƙwayar koda

Lalacewar cisplatin ga nama na koda yana shiga cikin rauni na oxidative da rauni mai kumburi.Daga oxidation index (H₂O₂), index antioxidant (SOD), da kuma kumburi index (HMGB-1) auna a cikin koda kyallen takarda na berayen a cikin kowane rukuni, za a iya sani cewa rauni na oxidative da ƙumburi da cisplatin ya haifar za a iya ragewa ta hanyar amfani da haɗin gwiwa.Ganoderma lucidum(Fig.

3).

Hoto.3 Tasirin cisplatin daGanoderma lucidumakan iskar shaka da kumburin ƙwayar koda

(3)Ganoderma lucidumyana haɓaka ƙarfin anti-apoptotic na ƙwayoyin koda

Ko da kuwa ko cisplatin yana haifar da mutuwar ƙwayar koda ta hanyar rauni na oxidative ko rauni mai kumburi, yanayin mutuwar ƙwayoyin koda shine "apoptosis."

A gaskiya ma, apoptosis shine tsarin al'ada na jiki don kawar da tsufa ko kwayoyin halitta don kiyaye ingancin rayuwa.Saboda haka, kyallen takarda da gabobin al'ada na iya gano ƙwayoyin apoptotic a kowane lokaci.Duk da haka, lokacin da yawancin ƙwayoyin sel suka sami apoptosis saboda abubuwan waje, aikin al'ada na kyallen takarda da gabobin zai shafi.

Hoto na 4 yana nuna matsayin apoptosis na ƙwayoyin koda na bera a kowace ƙungiya.Mafi duhu launi mai launi, mafi girman adadin apoptosis.Babu shakka, cisplatin na iya haifar da adadi mai yawa na apoptosis na renal cell, amma ƙwayoyin renal da Ganoderma lucidum ke kariya suna da kyakkyawan juriya ga apoptosis da cisplatin ya haifar.Lokacin da adadin matattun ƙwayoyin koda ya ragu, ƙimar raunin koda yana raguwa, kuma aikin koda ba shi da tasiri.

Hoto 4 Tasirin Cisplatin daGanoderma luciduma kan renal cell apoptosis

Ta hanyar kare hanta da koda ne kawai za a iya samun bege na kayar da cutar kansa.

Chemotherapy shine mafi yawan hanyoyin da ake buƙata don magance ciwon daji, amma yanayin "kashi biyu" na chemotherapy wanda ke kashe kwayoyin cutar kansa kuma yana lalata kwayoyin halitta na al'ada ba zai iya jurewa ga dukan marasa lafiya ba.

Watakila sha'awa mai karfi na iya jure ciwon ciki, amai, gudawa, bushewar baki, ciwon baki da sauran rashin jin dadi, amma hanta da kodan da ke daidaita magunguna ba za su iya kare su da karfi da karfi ba.

Da zarar babu hanta da koda mai aiki mai kyau, komai tsantsan kawar da kwayoyin cutar kansa, ba shi da amfani.

Labarun, "Lingzhi na iya inganta hanta da ke haifar da miyagun ƙwayoyi" da kuma "Lingzhi na iya inganta nephrotoxicity da ke haifar da miyagun ƙwayoyi", ta hanyar gwaje-gwajen dabba, ya sake amsa dalilan da ya sa marasa lafiya da ke karbar maganin chemotherapy tare da Lingzhi ba su da sauƙi a kayar da su ta hanyar gubar magungunan chemotherapy. .

Ana fatan waɗannan shaidun kimiyya za su iya gamsar da ƙarin marasa lafiya cewa za su iya ciGanoderma lucidumkafin, lokacin da kuma bayan chemotherapy, kuma ya kamata su ci shi kowace rana.Idan sun isa cin abinciGanoderma lucidumkowace rana, ana iya magance yawan guba na chemotherapy ga hanta da kodanGanoderma luciduma karon farko.

[Tsarin Bayanai]

1. Yasmen F Mahran, et al.Ganoderma lucidumYana Hana Cisplatin-Induced Nephrotoxicity ta hanyar Hana Siginar Karɓar Factor Factor Factor Epidermal da Apoptosis-Mediated Autophagy.Oxid Med Cell Longev.2020. doi: 10.1155/2020/4932587.

2. Hanan M Hassan, et al.Cire raunin Hanta da Cisplatin ya haifar a cikin beraye Ta hanyar Alarmin High-Mobility Group Box-1 Pathway byGanoderma lucidum: Nazarin Ka'idar da Gwaji.Drug Des Devel Ther.2020;14: 2335-2353.

KARSHE

Game da marubucin / Ms. Wu Tingyao

Wu Tingyao ya kasance yana bayar da rahoto da farkoGanoderma lucidumbayani

tun 1999. Ita ce marubucinWaraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).

★ Wannan labarin an buga shi ne a ƙarƙashin izini na musamman na marubucin, kuma mallakin GANOHERB ne ★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin GanoHerb ba ★ Idan ayyukan sun sami izini a yi amfani da su. Ya kamata a yi amfani da shi a cikin iyakar izini kuma a nuna tushen: GanoHerb ★ keta bayanin da ke sama, GanoHerb za ta ci gaba da ayyukanta na shari'a ★ Wu Tingyao ne ya rubuta ainihin rubutun wannan labarin da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.

Haɓaka Al'adun Kiwon Lafiyar Millennia

Taimakawa Wajen Lafiya Ga Kowa