4月 12, 2017 / University of Brawijaya / Heart International

文/呉廷耀

Long-term high-cholesterol diet can easily lead to abnormal blood lipids, and long-term abnormal blood lipids can lead to atherosclerosis. しかし, もしマンネンタケ polysaccharides is intervened, even if blood lipids are still abnormal, the risk of atherosclerosis is likely to be reduced.

“Heart International” published a report from the University of Brawijaya in Indonesia in 2017, proving thatマンネンタケ polysaccharide peptides (protein-rich β-D-glucan extracted fromマンネンタケ) have this protective effect.

Multiple effects against atherosclerosis

The researchers fed the rats with a high-cholesterol diet for 12 weeks. Three groups of rats were simultaneously fed with low, medium and high doses (50, 150, 300 mg/kg) のマンネンタケ polysaccharide peptides (PsP) preparation, which contains 20%マンネンタケ polysaccharide peptides, in the last 4 weeks of the experiment.

After the experiment, the health of the rats’ blood vessels was analyzed through four indicators, and the following results were found regarding the rats that ateマンネンタケ polysaccharide peptides:

1. The concentration of free radicals H2O2 in the serum is significantly lower — the low-density lipoprotein cholesterol (LDL-C) accumulated in the blood vessel wall is oxidized by free radicals, which is the first step in the formation of atherosclerosis. When free radicals decrease, the chance of atherosclerosis naturally decreases.

2. The secretion of IL-10, an anti-inflammatory cytokine, is reduced — it means that the degree of inflammation is mild, so there is no need for so much IL-10 to fight inflammation.

3. The number of “endothelial progenitor cells” that can be used to repair damaged blood vessel walls has increased — endothelial progenitor cells that circulate throughout the body with blood can repair blood vessel walls damaged by oxidation and inflammation. したがって, the increase of endothelial progenitor cells indicates that the possibility of repairing the damaged blood vessel wall is increased, and the chance of further evolving into atherosclerosis is relatively reduced.

4. The thickness of the inner wall of the aorta (intima and media) is close to normal — the cross-section of the arterial vessel can be divided into three layers from the inside to the outside: the wall of the blood vessel in contact with the blood flow is called the intima, which is composed of endothelial cells; the middle layer composed of smooth muscle is called the media. These two layers of vascular tissues are the most important lesion areas of atherosclerosis. したがって, when the thickness of the two layers is closer to normal, it means that the arteries are in a relatively healthy state.

Free radical concentration in rat serum

[注記] H2O2 is a kind of free radical. The lower its concentration, the less likely it is to form atherosclerosis. (Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

The concentration of anti-inflammatory cytokine in rat serum

 [注記] When the anti-inflammatory IL-10 concentration in the serum is not so high, it implies that the inflammation of the blood vessel wall may not be so severe, and the risk of atherosclerosis is also reduced. (Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

The number of endothelial progenitor cells in rat blood

[注記] Endothelial progenitor cells can repair damaged blood vessel walls. When their number increases, it means that the risk of atherosclerosis is reduced or can be delayed. (Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

The thickness of the arterial wall of the rat

[注記] The vascular “intima” and “media” are the most important lesion areas of atherosclerosis. The closer their thickness is to that of arteries under normal diet, the healthier the blood vessels will be.(Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

The protection ofマンネンタケ polysaccharide peptides on the cardiovascular system may not be fully reflected in the visible indicators.

The above experiments show that although the cause of atherosclerosis (high-fat diet) still exists, and blood lipids are still abnormal, マンネンタケ polysaccharide peptides can keep the artery blood vessels in a relatively healthy state through the triple effects of anti-oxidation, anti-inflammation and improving the chance of repairing damaged blood vessel walls. And the effect ofマンネンタケ polysaccharide peptides is proportional to its dosage.

Because the research team has previously confirmed through clinical studies that the use of thisマンネンタケ polysaccharide peptides preparation for adjuvant treatment of patients with angina pectoris can greatly improve inflammation, oxidative damage, blood sugar, and blood lipids in the body, thereby reducing the frequency and severity of angina pectoris. したがって, the clinical application potential ofマンネンタケ polysaccharide peptides is indeed worthy of our expectations.

Many studies in the past have used “lowering blood lipids to normal” as a specific indicator of the effectiveness ofマンネンタケ in protecting the cardiovascular system. しかし, research from Indonesia tells us that even if blood lipids have not returned to normal, or even if angina pectoris still occurs, we should not get disappointed withマンネンタケ because it has been working, but you may not be able to see its effect with your own eyes. As long as it is eaten often and for a long time, the protection ofマンネンタケ on the cardiovascular system will continue.

[Data Source] Wihastuti TA, 他. The inhibitory effects of polysaccharide peptides (PsP) of Ganoderma lucidum against atherosclerosis in rats with dyslipidemia. Heart Int. 2017; 12(1): e1-e7.

終わり

著者について/Mさん. 呉廷耀
ウー・ティンヤオ氏は、以来、霊芝に関する直接の情報を報告し続けている。 1999. 彼女はの著者です 霊芝による治癒 (4月に人民医学出版社に出版 2017).

★この記事は著者の独占的な許可を得て掲載されています.

★上記作品は転載禁止です, 著者の許可なく抜粋または他の方法で使用される.

★ For violations of the above statement, the author will pursue relevant legal responsibilities.

★この記事の原文はWu Tingyaoが中国語で執筆し、Alfred Liuが英語に翻訳しました。. 翻訳に齟齬があった場合 (英語) そしてオリジナル (中国語), 本来の中国人が勝つだろう. 読者に質問がある場合, 原作者に連絡してください, MS. 呉廷耀.