January 8, 2016/ Chinese Academy of Medical Sciences and Peking Union Medical College/ Frontiers in Microbiology

Text/Wu Tingyao

You must have seen some tragic character in a play who coughed for so long that he coughed up a mouthful of blood in one of his acute coughs……He was diagnosed with tuberculosis and had to be isolated so that he would not spread the disease to others. With the early intervention of modern medicine, few people got so sick, but the culprit, Mycobacterium tuberculosis, was ready to launch a massive attack when the immune system is compromised. Now, from China came the good news thatマンネンタケ spores and spore lipids may prophylactically inhibitMycobacterium tuberculosis.

A study published by Chinese Academy of Medical Sciences and Peking Union Medical College in “Frontiers in Microbiology” in January 2016 pointed out that the preventive administration ofマンネンタケ 抽出する(spores and spore lipid) can inhibit the replication and proliferation ofMycobacterium tuberculosis in mice and reduce the number ofMycobacterium tuberculosis in the lungs and spleen of mice.

All diseases caused byMycobacterium tuberculosis are collectively referred to as “tuberculosis”.Mycobacterium tuberculosis is mainly transmitted through droplets. It is highly infectious in confined spaces and close distances. Any tissues and organs in our body may be infected. しかし,“tuberculosis” caused by infection of the lungs is the most common. People with severe tuberculosis will die due to damage to their lungs.

Taking the statistics of Taiwan in 2012 as an example, the number of deaths due to tuberculosis in that year was more than 600, which was ten times the number of deaths caused by SARS in 2003. SARS comes once occasionally, but tuberculosis is always present. It is said that tuberculosis has not disappeared since the ancient Neolithic Age. Even if the invention of BCG controlled the scale of infection, but it still hasn’t completely blocked the threat of tuberculosis to mankind. We have to be cautious against it.

Don’t think that tuberculosis has nothing to do with you. It is understood that as many as one-third of the global population is infected with tuberculosis. You and I may be one of them. It’s just that the vast majority of infected people have no symptoms (prolonged cough for more than a month, weight loss, fever and night sweats) and low infectious “latent tuberculosis infection.”

実際には, as long as the immunity is sufficient, Mycobacterium tuberculosis can be kept in an “inactive” state. The problem is that when the immune system is compromised, especially when receiving radiotherapy, 化学療法, or being infected with HIV, Mycobacterium tuberculosis may have a big chance to attack. したがって, how to avoid infection and how to effectively suppress it after infection is the focus of the prevention and treatment of tuberculosis.

The research team of Chinese Academy of Medical Sciences and Peking Union Medical College first used C57BL/6 mice and a small amount ofMycobacterium tuberculosis to establish an animal experimental model similar to human “latent tuberculosis infection”, and further explored the anti-tuberculosis effect ofマンネンタケ. The team found that:

While the mice were infected withMycobacterium tuberculosis, they were simultaneously treated withマンネンタケ 準備 (15 mg of spores and 15 mg of spore lipid were taken orally each day for 16 weeks, then the experiment ended), the number ofMycobacterium tuberculosis in the lungs and spleen of the mice did not differ from that in the untreated group. しかし, if the same dose ofマンネンタケ can be given to the mice one month before the start of the experiment (infection), it can effectively reduce the number ofMycobacterium tuberculosis in the lungs and spleen of the mice. Especially in the first three to five weeks whenMycobacterium tuberculosis enters the body of the mouse, the inhibitory effect is more significant.

It was also observed in the experiment that there was no correlation between the number of immune cells in the peripheral blood of the mice, the number of proliferation ofMycobacterium tuberculosis, and the extent of lung and spleen lesions. しかし, in mice that ateマンネンタケ preparations before infection, during three to five weeks after infection with Mycobacterium tuberculosis, the dendritic cells in the peripheral blood decreased sharply, and the dendritic cells in the lungs increased greatly. This phenomenon may partly explain why pre-eatingマンネンタケ can inhibit theMycobacterium tuberculosis in the lungs of mice.

[ソース] Zhan L, 他. Prophylactic use of Ganoderma lucidum extract may inhibit Mycobacterium tuberculosis replication in a new mouse model of spontaneous latent tuberculosis infection. Front Microbiol. 2016 Jan 8;6:1490. 土肥: 10.3389/fmicb.2015.01490. eCollection 2015.

終わり

著者について/Mさん. 呉廷耀

Wu Tingyao has been reporting on first-handマンネンタケ information since 1999. 彼女はの著者です霊芝による治癒 (4月に人民医学出版社に出版 2017).

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★この記事の原文はWu Tingyaoが中国語で執筆し、Alfred Liuが英語に翻訳しました。. 翻訳に齟齬があった場合 (英語) そしてオリジナル (中国語), 本来の中国人が勝つだろう. 読者に質問がある場合, 原作者に連絡してください, MS. 呉廷耀.