5月 22, 2015 / 天津科学技術大学 / Lipids in Health and Disease

文/呉廷耀

There have been many scientific discussions on howマンネンタケ fruiting bodies can improve diabetes, but there are few related studies on the role ofマンネンタケ spores in this regard. この報告書, published in “Lipids in Health and Disease” by Tianjin University of Science and Technology, 中国, explores the effect of shell-brokenマンネンタケ 胞子粉(GLSP) with a shell-broken rate >99.9% on blood glucose, blood lipids and oxidative stress in type 2 糖尿病ラット.

The three groups of male rats participating in the experiment are all adults, と 8 rats in each group. Group 1: Normal control, normal rats with ordinary feed; Group 2: Model control, diabetic rats with ordinary feed without intervention; Group 3: GLSP, diabetic rats with ordinary feed, an intervention group utilizing GLSP of 1 g per day by oral gavages for 4 consecutive weeks. In rats, タイプ 2 diabetes results from the destruction of islet cells by injection of Streptozocin.

It was found that the blood glucose of diabetic rats that ate shell-brokenマンネンタケ spore powder began to drop from the second week and was 21% lower than that of diabetic rats that did not take Ganoderma lucidum by the end of the fourth week, but it was still four times the blood glucose of normal rats.

In terms of blood lipid compositions, compared with diabetic rats that did not eat the shell-brokenマンネンタケ 胞子粉, the total cholesterol of diabetic rats in theマンネンタケ group was reduced by 49%, and their triglycerides were reduced by 17.8%. However, these indexes of both of them were far away from those of normal rats (their total cholesterol is about five times that of normal rats, and their triglycerides are one and a half times as much.) Only HDL-C, commonly known as “good cholesterol,” rises to levels close to that of normal rats.

Diabetes can significantly increase the oxidative stress in the body, but eating shell-brokenマンネンタケ spores for four weeks can significantly reduce the concentration of MDA (malondialdehyde) and ROS (reactive oxygen species) in the blood of diabetic rats. These two values are still higher than those of normal rats, but the two important antioxidant enzymes, GSH-Px (glutathione peroxidase) and SOD (superoxide dismutase) are also higher than those of normal rats, showing that shell-brokenマンネンタケ spores can effectively enhance the antioxidant capacity of diabetic rats, thereby alleviating excessive oxidative stress.

Further analysis revealed that several genes related to lipid metabolism (Acox1, ACC, Insig-1 and Insig-2), as well as genes related to glycogen synthesis (GS2 and GYG1), have more expression levels than those diabetic rats who did not eat shell-brokenマンネンタケ 胞子. However, some genes showed no significant differences, including SREBP-1, Acly, Fas, Fads1, Gpam and Dgat1 involved in lipid metabolism, and PEPCK and G6PC1 involved in carbohydrate metabolism.

All in all, although there is still some distance from “returning to normal”, the shell-brokenマンネンタケ spore powder has shown its benefits for type 2 diabetes within a month, including lowering blood glucose and blood lipids. From the perspective of gene expression, its mechanism of action may be related to promoting glycogen synthesis, inhibiting gluconeogenesis (inhibiting the conversion of non-carbohydrates into glucose), and regulating the proportion of HDL in cholesterol. As for what active ingredients make the shell-brokenマンネンタケ spore powder effective, this paper does not specifically elaborate..

[ソース] Wang F, 他. Effect of マンネンタケ spores intervention on glucose and lipid metabolism gene expression profiles in type 2 糖尿病ラット. Lipids Health Dis. 2015 5月 22;14:49. 土肥: 10.1186/s12944-015-0045-y.

終わり

著者について/Mさん. 呉廷耀

ウー・ティンヤオ氏は、以来、霊芝に関する直接の情報を報告し続けている。 1999. 彼女はの著者です霊芝による治癒 (4月に人民医学出版社に出版 2017). 

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★上記作品は転載禁止です, 著者の許可なく抜粋または他の方法で使用される.

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★この記事の原文はWu Tingyaoが中国語で執筆し、Alfred Liuが英語に翻訳しました。. 翻訳に齟齬があった場合 (英語) そしてオリジナル (中国語), 本来の中国人が勝つだろう. 読者に質問がある場合, 原作者に連絡してください, MS. 呉廷耀.