The main components of영지버섯 alcohol extract are triterpenoids. It is said that영지버섯 triterpenoids have anti-tumor effects, but do you know what actual anti-tumor effects can영지버섯 triterpenoids play after entering the gastrointestinal tract?

The team of Professor Jianhua Xu and Professor Peng Li from the School of Pharmacy of Fujian Medical University have published a series of research reports. Using the fruiting bodies of영지버섯 provided by Fujian Xianzhilou Biological Science and Technology Co., Ltd. as raw materials, through a specific ethanol extraction process, they obtained two components of영지버섯 triterpenoids: GLA and GLE, which were fed to experimental animals with cancer cells or tumors to see what would happen.

It was found that the triterpenoid components of영지버섯 have at least the significance of “inhibiting tumor growth, prolonging survival time and improving the effectiveness of chemotherapy”.

Slow down the tumor growth.

The effect is positively correlated to the dose of triterpenoids.

The researchers first subcutaneously inoculated mice with ascitic type hepatocellular carcinoma cell line (H22) or sarcoma cell line (S180), 그리고 24 hours later, they were fed with low, 중간 및 고용량 (0.5, 1, 그리고 2 g/kg per day) of GLA for 7 연속 일; the chemotherapy group was given cyclophosphamide (CTX) (30 mg/kg) every 3 날; the control group was given no treatment.

On the 8th day of the experiment, the tumor weights of the mice in each group were evaluated. The results showed that GLA, a triterpenoid component of영지버섯, significantly slowed down the growth of ascitic type hepatocellular carcinomas and sarcomas, and the effect was positively correlated with the dose.

Direct tumor suppression in immunocompromised conditions

The above experimental results were obtained under the condition of normal immune function. In order to understand whether the inhibition of tumor growth by GLA, a triterpenoid component of영지버섯, is related to immune function, the researchers conducted the following experiments:

The colon cancer cell line (Colon-26) was inoculated into nude mice whose immune function was not normal. After the tumor grew out, the medium and high doses of GLA were fed again, and the tumor inhibitory effect was still excellent.

This shows that GLA can directly inhibit tumor growth, and its mechanism of action is different from that of영지버섯 polysaccharides to enhance the anti-cancer ability of the immune system and inhibit tumors.

Not only inhibits tumor growth but also prolongs life

게다가, through GLE, another영지버섯 triterpene component, the team of Prof. Jianhua Xu and Prof. Peng Li also observed that영지버섯 triterpenoids not only inhibited tumor growth but also prolonged the survival time of tumor-bearing mice after treatment.

According to its published report, GLE (Extract from영지버섯) is an extract isolated and purified from영지버섯 by the Institute of New Medicine of Fujian Medical University. 1 gram of GLE is equivalent to 93 그램영지버섯 raw medicinal materials, and its영지버섯 triterpenoid content is 56.7%.

The experimental results show that compared with the aforementioned GLA, GLE can exert the same excellent inhibitory effect on mouse ascitic type hepatocellular carcinomas and sarcomas at a lower dose (one-fourth of GLA) under the same experimental conditions, and both can reach or exceed the target specified in the evaluation of the efficacy of traditional Chinese medicine – the tumor inhibition rate of more than 30%.

The experiment also found that after all treatments were stopped (GLE or chemotherapy drugs were no longer given), the sarcoma mice that originally ate GLE could live longer, and their survival time was positively correlated with the previous dose of GLE. 그 중, the survival time of the high-dose GLE group was even significantly longer than that of the positive control group who had previously received chemotherapy.

According to the researcher’s observation, although chemotherapy has an obvious tumor-suppressing effect, the body weight of sarcoma mice will be affected and their fur will also become poorer during the medication process; on the other hand, the tumor suppression rate of the high-dose GLE group is close to that of chemotherapy. And GLE produces no adverse reactions caused by chemotherapeutic drugs, and it can also prolong the survival time, which shows that the triterpenoid components of영지버섯 have certain safety and effectiveness, and have certain help for the “quality” coexistence with cancer.

It can assist chemotherapy and improve the effect of tumor suppression

게다가, Professor Peng Li’s team also found through another animal experiment that the triterpenoid components of영지버섯 can aid chemotherapy drugs.

They first inoculated the HER2-positive human breast cancer cell line (SKBR-3) in immune-deficient nude mice, and after tumors grew out, they fed these nude mice 250 mg/kg of GLE every day and gave paclitaxel (PTX) treatment (intravenous injection) once every three days.

후에 14 days of treatment, it was found that compared with GLE or paclitaxel alone, the combination of the two had a significantly better inhibitory effect on tumors.

영지버섯 triterpenoids with established efficacy and stable quality help to coexist with cancer every day.

The above research results show the benefits of specific raw material sources, specific extraction methods, and specific composition of영지버섯 triterpenoid components to tumor-bearing animals after passing through the digestive system. Thanks to long-term stable experimental materials, researchers can see good experimental results in experimental animals time and time again.

사실은, the anti-tumor effect of영지버섯 triterpenoids has long been scientifically affirmed. The main problem is whether the “영지버섯” that consumers choose really has such active ingredients for the long term. 결국, the word “영지버섯” on the box does not mean that the product must contain영지버섯 triterpenoids. 게다가, products marked with the word “triterpenoids” may not produce the effects of영지버섯 triterpenoids.

The scientifically proven efficacy comes from the ingredients, and the ingredients are closely related to the extraction process and the source of the raw materials. Stable and consistent quality requires standardized management and control in each link to achieve.

When these conditions are met, it is possible to transform the benefits of영지버섯 triterpenoids into the hope of coexisting with cancer and survival with cancer for a long time.

참고자료

1.Xiaoxia Wei et al. Study on the antitumor effect of GLA, a triterpenoid component of Ganoderma lucidum, in vitro and in vivo. Journal of Fujian Medical University, 2010, 44(6): 417-420.
2.Peng et al. Experimental study on the antitumor effect of Ganoderma lucidum extract. Chinese Journal of Modern Applied Pharmacy, 2011, 28(9): 798-792.
3.Feng Liu et al. Antitumor effects of GLE, a triterpenoid component of Ganoderma lucidum, in vitro and in vivo. Chinese Journal of New Drugs, 2012, 21(23): 2790-2793.
4.Zhiqiang Zhang et al. Ganoderma lucidum triterpenoid components enhance paclitaxel-induced apoptosis of HER2+ breast cancer cells. Journal of Fujian Medical University, 2016, 50(1): 1-5.

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★ 이 기사의 원문은 Wu Tingyao가 중국어로 작성하고 Alfred Liu가 영어로 번역했습니다.. 번역 내용에 차이가 있는 경우 (English) 그리고 원본 (중국인), 원래 중국어가 우선합니다. 독자들이 궁금한 점이 있으면, 원작자에게 연락주세요, 양. Wu Tingyao.

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