3월 1, 2018 / Russian Academy of Sciences / Phytomedicine

Text / 우팅야오

In March 2018, a paper published in Phytomedicine by the Institute of Cytology and Genetics of the Russian Academy of Sciences confirmed that after seven weeks of feeding영지버섯 (Reishi) fruiting body water extract to rats suffering from inherited stress-induced arterial hypertension, the hypotensive effect of영지버섯 water extract is comparable to that of Losartan (see Figure 1).

The animal experiment also found that for hypertensive rats treated with영지버섯 water extract, the blood flow volume of their carotid artery substantially increased, about twice as much as that of those without any treatment (see Figure 2). 동시에, the carotid artery diameter and blood flow rate also increased significantly. This means that the blood flow to the rat’s brain is not reduced by the drop in blood pressure but instead becomes more active and abundant under the influence of영지버섯. In contrast, although the carotid artery diameter of the rats in the hypotensive drug group increased, the blood flow rate did not exceed that of the control group, and the blood flow volume was not significantly different from that of the control group.

In March 2018, a paper published in Phytomedicine by the Institute of Cytology and Genetics of the Russian Academy of Sciences confirmed that after seven weeks of feeding영지버섯 (Reishi) fruiting body water extract to rats suffering from inherited stress-induced arterial hypertension, the hypotensive effect of영지버섯 water extract is comparable to that of Losartan (see Figure 1).

The animal experiment also found that for hypertensive rats treated with영지버섯 water extract, the blood flow volume of their carotid artery substantially increased, about twice as much as that of those without any treatment (see Figure 2). 동시에, the carotid artery diameter and blood flow rate also increased significantly. This means that the blood flow to the rat’s brain is not reduced by the drop in blood pressure but instead becomes more active and abundant under the influence of영지버섯. In contrast, although the carotid artery diameter of the rats in the hypotensive drug group increased, the blood flow rate did not exceed that of the control group, and the blood flow volume was not significantly different from that of the control group.

Figure 2 The effect of영지버섯 water extract on arterial blood flow volume

[메모] The experiment process is the same as above. After seven weeks of treatment, the carotid blood flow volume of the Reishi group was significantly higher than that of the other two groups. (Source/Phytomedicine.2018 Mar 1; 41:1-6.)

Further analysis of the 12 main neurotransmitters secreted by the cerebral cortex of each group of rats, it was found that the water extract of영지버섯 fruiting body can change the ratio of certain neurotransmitters, making the inhibitory neurotransmitters (such as glycine, referred to as Gly) and excitatory neurotransmitters (such as glutamine, referred to as Glx) closer to a balanced state, and such a state is conducive to normal blood pressure.

This result shows that compared to Losartan, which antagonizes the antagonist of AT1 receptors of angiotensin Ⅱ to dilate blood vessels and control blood pressure, 영지버섯 water extract is more complicated in regulating blood pressure and is related to the regulation of the cranial nervous system.

The animal model used in the experiment is “inherited stress-induced arterial hypertension”, 즉, the constitution inherited from the father or mother that easily causes high blood pressure, and mental stress is the main inducing factor. This is actually in line with the condition of most patients with hereditary hypertension of unknown etiology: autonomic nervous system disorders caused by stress (the regulatory function imbalance between the sympathetic nerve dominated by excitatory neurotransmitters and the parasympathetic nerve dominated by inhibitory neurotransmitters) makes blood pressure always high and difficult to return to normal levels.

If you don’t understand the relationship between autonomic nerve and blood pressure, you can imagine that blood pressure spikes due to emotional excitement (which is dominated by the sympathetic nervous system) while watching a football game, but blood pressure drops back to normal after a period of rest (which is dominated by the parasympathetic nervous system). This is the normal regulation mechanism. Once the blood pressure cannot return to normal by rest, sleep, and emotional relaxation, there will be a problem of high blood pressure. As for whether the blood pressure reaches the medically defined disease condition that requires medication, it depends on whether the systolic or diastolic blood pressure exceeds the prescribed value– as long as one of them is abnormal, it is considered high blood pressure.

There are several areas of the brain that can affect blood pressure and mood. Normally, they are regulated by the cerebral cortex (the “brain’s highest cognitive ability control center”). Previously, another group of researchers from the Russian Academy of Sciences has confirmed that in rats with “inherited stress-induced arterial hypertension”, the cerebral cortex secretes more excitatory neurotransmitters, keeping the blood pressure high. Now, in experiments with영지버섯, it has been observed that oral administration of영지버섯 water extract for seven consecutive weeks can regulate the neurotransmitters secreted by the cerebral cortex and fundamentally improve hypertension.

As for those hypertensive rats that ate영지버섯 fruiting body extract, their cerebral blood flow increased and their blood flow rate increased. Therefore, the researcher pointed out at the end of the report that영지버섯 extract may have a potential nootropic effect.

Whether eating영지마 lucidum can really produce nootropic effects, it has to be proved by another experiment. But for patients with high blood pressure whose etiology is unknown (not caused by diabetes and kidney disease), 영지버섯 products containing영지버섯 fruiting body extracts should be worth a try. At least영지버섯 does not produce side effects such as dizziness, nasal congestion, cough, and nausea common to general antihypertensive drugs.

It is worth mentioning that past studies have confirmed that영지버섯 triterpenes can inhibit the activity of angiotensin converting enzyme (ACE) so that Angiotensin I secreted by the kidney cannot be catalyzed by ACE into Angiotensin II that can promote vasoconstriction. Now, the water extract of영지버섯 fruiting body, which is mainly composed of polysaccharides, has been proven to improve high blood pressure by regulating the cranial nervous system. The complementarity of triterpenoids and polysaccharides once again confirms that영지버섯 with complete ingredients (containing both triterpenoids and polysaccharides) is the ideal choice.

[원천] Shevelev OB, 외. Hypotensive and neurometabolic effects of intragastric Reishi (영지버섯) administration in hypertensive ISIAH rat strain. Phytomedicine. 2018 Mar 1; 41:1-6.

끝

저자 소개 / 씨. 우팅야오

Wu Tingyao는 이후 직접 Ganoderma 정보를 보고해 왔습니다. 1999. 그녀는 다음의 저자입니다.Ganoderma로 치유 (4월 인민의학출판사에 게재 2017). 

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