우팅야오
In mid-2020, 델타 과학대학교 연구팀 & 기술과 이집트의 Ain Shams 대학이 합류하여 “Drug Design” 보고서 출판, Development and Therapy” and “Oxidative Medicine and Cellular Longevity” proving that영지마명쾌함 (Lingzhi 또는 Reishi 버섯이라고도 함) can greatly reduce liver and kidney injury caused by cisplatin through the triple effects of anti-oxidation, anti-inflammation and anti-apoptosis.
Following the “Part 1영지버섯 protects the liver vs. cisplatin hepatotoxicity” of the previous article, the author will introduce how much영지버섯‘s kidney-protecting effect can resist the nephrotoxicity caused by cisplatin in this article in the hope that the data and evidence based on science will bring more confidence to friends who seek to reduce the side effects of chemotherapy.
Part 2영지버섯protects the kidney vs. Cisplatin nephrotoxicity
Like the animal experiment on “영지버섯 protects the liver vs. Cisplatin hepatotoxicity”, healthy rats are divided into 6 groups for a 10-day experiment on ”영지버섯 protects the kidney vs. Cisplatin nephrotoxicity”:
◆Control Group (Cont): the group that does not receive any treatment;
◆영지버섯 그룹(GL): the group that are not injected with cisplatin but eats영지버섯 매일;
◆Cisplatin Group (CP): the group that is only injected with cisplatin but does not eat영지버섯;
◆Everyday Group (Daily): the group that is injected with cisplatin and eats영지버섯 매일;
◆Every Other Day Group (EOD): the group that is injected with cisplatin and eats영지버섯 every other day;
◆Intraperitoneal Group (i.p): the group that is injected cisplatin and receives intraperitoneal injection of영지버섯.
All those who received cisplatin were injected intraperitoneally with 12 mg/kg of Cisplatin on the third day of the experiment to trigger acute kidney injury; those who received the intraperitoneal injection of영지버섯 were injected once on the second and sixth days of the experiment. For the groups that ate영지버섯중, whether they ate it every day or every other day, it was calculated from the first day of the experiment.
다시 말해서, in this experimental design, all groups receiving cisplatin and영지버섯 were given영지버섯 before the cisplatin injection. This is slightly different from the animal experiment on “영지버섯 protects the liver vs. Cisplatin hepatotoxicity” in which cisplatin was given on the first day of the experiment (Cisplatin and영지버섯 are used together from the beginning, or cisplatin was given first and then영지버섯).
그만큼영지버섯 material used in this experiment is the same as the영지버섯 material used in the animal experiment on “영지버섯protects the liver vs. Cisplatin hepatotoxicity”. They all contain triterpenes, sterols, 다당류, polyphenols and flavonoids. The dose of영지버섯 given, whether orally or by injection, ~이다 500 mg/kg/일.
(1) Ganoderma lucidum reduces kidney tissue injury
After the 10-day experiment, blood was drawn to detect the creatinine and blood urea nitrogen content of rats in each group. The results found that cisplatin increased these two indexes sharply, which means that the kidney tissue was seriously injured; 만약에영지버섯 is used at the same time, the increase of these two indicators will be much reduced, especially eating영지버섯 every day produces a more obvious protective effect (Fig.
Fig. 1 Effects of Cisplatin and영지마명쾌함on Kidney Injury Index
The same results were also reflected in the stained sections of kidney tissues of rats in each group (Fig. 2). When cisplatin causes renal congestion, renal tubule dilatation, and necrosis, shedding, or vacuolar degeneration of renal tubular epithelial cells in rats (there are various arrows indicating injury on the stained section figure), the kidney tissues of the rats of the Everyday Group (Daily) suffered the least injury (there is no arrow representing injuries on the stained section figure).
Since cisplatin accumulates in the epithelial cells of the renal tubules in large quantities, the injury of the renal tubules naturally becomes the main observation target. It can be clearly seen from the quantified degree of renal tubular injury that영지버섯 can significantly reduce the renal tubular injury caused by cisplatin. 특히, 식사영지버섯 every day produces the most significant protective effect.
T refers to renal tubules while G refers to glomeruli on the figures of tissue sections; the arrow points to renal congestion, tubular dilatation, necrosis, shedding, or vacuolar degeneration of renal tubule epithelial cells due to renal tissue injury.
Fig. 2 Effects of Cisplatin and영지버섯 on kidney tissue
(2) 영지버섯 enhances the anti-oxidative and anti-inflammatory ability of kidney tissue
The damage of cisplatin to kidney tissue is involved in oxidative injury and inflammatory injury. From the oxidation index (H2O2), antioxidant index (잔디), and inflammation index (HMGB-1) measured in the kidney tissues of rats in each group, it can be known that the oxidative injury and inflammatory injury caused by cisplatin can be reduced by the combined use of영지버섯 (Fig.
3).
Fig. 3 Effects of cisplatin and영지버섯 on the oxidation and inflammation indexes of kidney tissue
(3) 영지버섯 enhances the anti-apoptotic ability of kidney cells
Regardless of whether cisplatin causes kidney cell death through oxidative injury or inflammatory injury, the death mode of kidney cells is “apoptosis.”
사실은, apoptosis is the body’s normal mechanism to eliminate aging or abnormal cells in order to maintain the quality of life. 그러므로, normal tissues and organs can detect apoptotic cells at any time. 하지만, when a large number of cells undergo apoptosis due to external factors, the normal operation of tissues and organs will be affected.
Fig. 4 shows the apoptosis status of rat kidney tissues in each group. The darker the staining color, the greater the number of apoptosis. 확실히, cisplatin can cause a large number of renal cell apoptosis, but the renal cells protected by Ganoderma lucidum have good resistance to apoptosis caused by cisplatin. When the number of dead kidney cells decreases, the degree of kidney injury is reduced, and kidney function is less affected.
Fig. 4 Effects of cisplatin and영지버섯 on renal cell apoptosis
Only by protecting the liver and kidneys can there be the hope of defeating cancer.
Chemotherapy is the most common and necessary means to treat cancer, 하지만 암세포를 죽이고 정상세포를 손상시키는 화학요법의 '양날' 특성은 모든 환자가 견딜 수 없는 일이다..
아마도 강한 의지가 메스꺼움을 견딜 수 있을 것입니다., 구토, 설사, 입이 마르다, 구강 궤양 및 기타 불편함, 그러나 약물을 대사하는 간과 신장은 강한 의지로 보호할 수 없습니다..
간과 신장이 제대로 기능하지 않으면, 아무리 암세포 제거가 철저해도, 그것은 쓸모가 없다.
기사, “영국은 약물 유발성 간독성을 개선할 수 있습니다” 및 “링국은 약물 유발성 신독성을 개선할 수 있습니다”, 동물 실험을 통해, 영국의 보조화학요법을 받는 암환자들이 화학요법 약물의 독성에 쉽게 쓰러지지 않는 이유에 대해 다시 한 번 답해 주셨습니다..
It is hoped that these scientific evidences can convince more patients that they can eat영지버섯 ~ 전에, during and after chemotherapy, and they should eat it every day. If they eat enough영지버섯매일, the toxicity of chemotherapy to the liver and kidneys can be mostly resolved by영지버섯 in the first time.
[데이터 소스]
1. Yasmen F Mahran, et al.영지버섯 Prevents Cisplatin-Induced Nephrotoxicity through Inhibition of Epidermal Growth Factor Receptor Signaling and Autophagy-Mediated Apoptosis. 셀 수명이 긴 산화물. 2020. 도이: 10.1155/2020/4932587.
2. Hanan M Hassan, 외. Suppression of Cisplatin-Induced Hepatic Injury in Rats Through Alarmin High-Mobility Group Box-1 Pathway by영지버섯: Theoretical and Experimental Study. Drug Des Devel Ther. 2020; 14: 2335–2353.
끝
저자 소개 / 씨. 우팅야오
Wu Tingyao가 직접 보고해 왔습니다.영지버섯 정보
~부터 1999. 그녀는 다음의 저자입니다.Ganoderma로 치유 (4월 인민의학출판사에 게재 2017).
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★ 이 기사의 원문은 Wu Tingyao가 중국어로 작성하고 Alfred Liu가 영어로 번역했습니다.. 번역 내용에 차이가 있는 경우 (영어) 그리고 원본 (중국인), 원래 중국어가 우선합니다. 독자들이 궁금한 점이 있으면, 원작자에게 연락주세요, 양. 우팅야오.
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