영지 다당류 및 대장염

지난 8월 아베 신조 일본 총리의 갑작스러운 사임 발표가 아니었다면 28, 평생 치료가 필요한 자가면역질환인 궤양성 대장염을 많은 사람들이 눈치 채지 못했을 것입니다..

대부분의 사람들은 박테리아 감염으로 인한 며칠간의 복통과 설사를 견딜 수 없습니다., 혈변 등의 증상이 있는 궤양성 대장염은 물론이고, 발열, 구토, 탈수, 그리고 체중 감량. 전자는 약으로 치료할 수 있는 반면, 후자는 원인을 알 수 없는 장점막의 염증 및 손상이다.. 약물은 질병을 제거할 수 없으며 염증을 억제하고 관련 증상을 완화시킬 수 있을 뿐입니다..

사실은, the problem of ulcerative colitis lies in “the inflammation that shouldn’t occur never stops.” When the immune system that initiates the inflammatory response fails, the inflammatory response becomes a health killer and may even cause cell cancer.

장 용핑 (가운데), 신화통신 총경리실 총경리 및 관련 담당자가 GANOHERB 팀과 단체 사진을 찍었습니다.

국가 브랜드 프로젝트는 신화 통신사가 국가 브랜드 프로젝트를 통해 중국을 활성화한다는 전략을 제공하기 위해 만든 국가 차원의 커뮤니케이션 프로젝트입니다.. 선정된 기업은 항상 “중심 과제에 집중하고 전반적인 이익에 봉사”하는 등 다양한 엄격한 조건을 충족해야 합니다., 국가 발전 전략에 의식적으로 참여하고 봉사합니다., 강한 사회적 책임감을 가지고, 업계 최고의 독립적인 혁신 역량, 사회적 가시성 및 브랜드 평판 향상, 좋은 기업 문화, 장인 정신을 고취하다, 정도경영을 견지하고 법규를 준수한다., 중국 제조, 중국 품질을 대표하는 우수한 품질을 보유하고 있습니다., 그리고 공공복지에 열의를 갖고, 국가 목표 빈곤 완화 계획을 적극적으로 이행합니다., 종합적인 강점 순위 측면에서 업계 선두에 랭크되었습니다..

브랜드는 기업이 전반적인 경쟁력을 향상시키는 중요한 수단입니다.. 이번에 "신화통신 국가 브랜드 프로젝트"에 선정되어 중국 레이시 산업에서 GANOHERB 브랜드의 선두 위치를 확인했습니다.. Xinhua News Agency와의 강력한 협력은 "GANOHERB"의 브랜드 가치와 브랜드 강점을 더욱 강화하고 중국 Lingzhi의 브랜드 매력을 더욱 잘 보여줄 것입니다..

수치 1 Schematic diagram of the large intestine and endoscopic images of ulcerative colitis

The large intestine includes the cecum, colon, and rectum (left picture): the cecum is connected to the small intestine to prevent the reflux of food entering the large intestine; the colon controls the digestion and absorption function of the large intestine and forms the residue into feces, which are temporarily stored in the rectum for discharge. Ulcerative colitis occurs mainly in the mucosal tissues of the colon and rectum. Endoscopy will show inflammation and ulcers in the colonic mucosa. (Photo/Wikimedia Commons)

Reducing inflammation is only palliative while regulating immunity can effect a permanent cure.

Regarding the problem of immune disorders, existing drugs can only set about the “symptoms” caused by immune disorders.

“Regulating immunity and strengthening and consolidating body resistance” is originally the gold-lettered signboard of the Reishi mushroom. According to the scientific literature published so far, it is known that whether it is polysaccharides or triterpenes from Reishi mushroom, they can regulate immunity and play an important role in the improvement of ulcerative colitis.

Reishi mushroom polysaccharides reduce the severity of colitis.

두 보고서는 중국 의과대학 면역학과가 Journal of Immunology Research에 발표했습니다. 2018 그리고 Food지에 게재된 보고서 & 진안대학교 식품공학과 영양연구 2019 우연히 예방 용량으로 Ganoderma lucidum 다당류를 경구 투여하는 것이 입증되었습니다. 2 에게 3 몇 주만 지나면 궤양성 대장염 발병의 심각성을 크게 줄일 수 있습니다. (수치 2).

수치 2 Ganoderma lucidum 다당류는 궤양성 대장염의 증상을 감소시킵니다..

Ganoderma lucidum 다당류가 보충된 마우스 (100 mg/kg/일) 2주 전에는 체중 감소가 적고 질병 활성도가 낮았습니다. (가벼운 체중 감량, 설사와 혈변) 결장의 길이가 길어짐 (염증과 손상이 적음을 나타냅니다.) 덜 심각한 조직 손상 (including the degree of mucosal tissue damage and leukocyte infiltration) when the acute attack of ulcerative colitis was induced. (Source/Reference 1).

Why can Ganoderma lucidum polysaccharides improve ulcerative colitis? Two research reports analyzed from two different perspectives: “regulating immune response” and “regulating intestinal ecology”:

Mechanism 1: Ganoderma lucidum polysaccharides regulate inflammation and inhibit Th17 cells

A study by China Medical University found that mice that had been supplemented with Ganoderma lucidum polysaccharides in advance had fewer inflammation-related cytokines in the colorectal mucosal tissue during the acute attack of ulcerative colitis (수치 3). There were not so many natural killer cells and Th17 cells that promoted inflammation, but B cells that can secrete IgA, the main antibody of mucosal tissue, grew against the trend.

These immune changes not only help alleviate the inflammatory response and help the intestines to resist possible infections but also have the opportunity to correct the imbalance of Th17 cells and regulatory T cells (트레그) and improve the autoimmune problem of ulcerative colitis from the source.

Every autoimmune disease has a key factor that promotes its onset and exacerbates its deterioration. For ulcerative colitis, it is one of the T-cell subtypes called Th17 cells. The secreted cytokine IL-17 (IL-17A is the most important one) can fight various bacterial and fungal infections through inflammation and is an important role of the intestinal immune barrier.

Excess is just as bad as deficiency. Th17 cells and “regulatory T cells” will check and balance each other, with more on one side and less on the other. The function of regulatory T cells is to maintain autoimmune tolerance (not to launch an immune response to one’s own family members) and to put the brakes on the inflammatory response in a timely manner. 그러므로, when Th17 cells are too active, regulatory T cells will become weaker and more inflammation will occur.

The imbalance of these two groups of cells is considered to be the key to detonating ulcerative colitis. In the above-mentioned study of China Medical University, although the regulatory T cells in the mucosal tissues of the mouse large intestine were not increased by the intervention of Ganoderma lucidum polysaccharides, the secretion of Th17 cells and IL-17A has been significantly reduced (수치 3), which should be a good start for the balance between Th17 cells and regulatory T cells.

수치 3 Ganoderma lucidum polysaccharides regulate immunity and improve colitis.

For mice that had been supplemented with Ganoderma lucidum polysaccharide for two weeks (100 mg/kg/일), during the acute attack of ulcerative colitis, the inflammation-related tumor necrosis factor (TNF-α) and interleukins such as IL-1β,  IL-6, IL-4, IL-17A in the colonic mucosa tissue significantly reduced, and the level of Th17 cells also significantly reduced, but the level of regulatory T cells was not statistically significant (in comparison with the colitis mice that had not been supplemented with Ganoderma lucidum polysaccharides). (Source/Reference 1)

Mechanism 2: Ganoderma lucidum polysaccharides regulate the intestinal ecology and help adjust the imbalanced immunity.

Research from Jinan University found that Ganoderma lucidum polysaccharides can adjust the ratio of the intestinal flora of experimental rats (such as reducing the pathogenic flora, increasing the flora that resists inflammation and secrets short-chain fatty acid), and promote the intestinal tract to secrete more short-chain fatty acids (수치 4), which in turn regulates the immune response of the intestinal mucosa and reduces the severity of ulcerative colitis.

A large part of the material absorbed by the large intestine is produced by bacteria living in the large intestine. When those polysaccharides that cannot be digested by the small intestine (such as dietary fiber, Ganoderma lucidum 다당류) enter the large intestine, they will be broken down into various short-chain fatty acids by a group of bacteria that depend on them for a living. These acetic acids, propionic acids and butyric acids not only nourish the intestinal cells but also protect the mucosal barrier and regulate the immune response. Compared with this kind of friendly bacteria, some intestinal bacteria are the promoters of inflammation. When the proportion of each other is out of balance, it is often the beginning of an illness.

Studies have confirmed that the imbalance of the intestinal flora ratio and insufficient secretion of short-chain fatty acids can cause immune disorders and induce ulcerative colitis. Ganoderma lucidum polysaccharides can reverse the situation, regulate immunity by regulating intestinal ecology, and further improve ulcerative colitis. Isn’t it cool? (To be continued-Ganoderma triterpenes)

수치 4 Ganoderma lucidum polysaccharides regulate intestinal ecology and improve colitis

The mice were fed with Ganoderma lucidum polysaccharides for 3 주 (393.75 mg/kg/일) and was then induced an acute attack of ulcerative colitis. Their inflamed intestines usually have the phenomenon of increased Proteobacteria flora, decreased Firmicutes flora, and decreased short-chain fatty acid secretion. 하지만, in the large intestine protected by Ganoderma lucidum polysaccharides, the two major floras have experienced significant growth and decline, and the content of short-chain fatty acids has also risen sharply. (Source/Reference 2)

【참고자료】

Wei B, 외. Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides. JImmunolRes. 2018 May 20;2018:2906494. 도이: 10.1155/2018/2906494. e컬렉션 2018.2. Xie J, et al. Ganoderma lucidum polysaccharide improves rat DSS-induced colitis by altering cecalmicrobiota and gene expression of colonic epithelial cells. Food Nutr Res. 2019 2월 12;63. 도이: 10.29219/fnr.v63.1559. e컬렉션 2019.

저자 소개 / 씨. 우팅야오
Wu Tingyao는 이후 직접 Ganoderma lucidum 정보를 보고해 왔습니다. 1999. 그녀는 “Ganoderma lucidum”의 저자입니다.: 설명할 수 없을 만큼 독창적이다” (4월 인민의학출판사에 게재 2017).

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