5월 22, 2015 / Tianjin University of Science and Technology / Lipids in Health and Disease

문자/우 팅야오

There have been many scientific discussions on how영지버섯 fruiting bodies can improve diabetes, but there are few related studies on the role of영지버섯 spores in this regard. This report, published in “Lipids in Health and Disease” by Tianjin University of Science and Technology, China, explores the effect of shell-broken영지버섯 포자 가루(GLSP) with a shell-broken rate >99.9% on blood glucose, blood lipids and oxidative stress in type 2 diabetic rats.

The three groups of male rats participating in the experiment are all adults, with 8 rats in each group. Group 1: Normal control, normal rats with ordinary feed; Group 2: Model control, diabetic rats with ordinary feed without intervention; Group 3: GLSP, diabetic rats with ordinary feed, an intervention group utilizing GLSP of 1 g per day by oral gavages for 4 consecutive weeks. In rats, type 2 diabetes results from the destruction of islet cells by injection of Streptozocin.

It was found that the blood glucose of diabetic rats that ate shell-broken영지버섯 spore powder began to drop from the second week and was 21% lower than that of diabetic rats that did not take Ganoderma lucidum by the end of the fourth week, but it was still four times the blood glucose of normal rats.

In terms of blood lipid compositions, compared with diabetic rats that did not eat the shell-broken영지버섯 포자 가루, the total cholesterol of diabetic rats in the영지버섯 group was reduced by 49%, and their triglycerides were reduced by 17.8%. 하지만, these indexes of both of them were far away from those of normal rats (their total cholesterol is about five times that of normal rats, and their triglycerides are one and a half times as much.) Only HDL-C, commonly known as “good cholesterol,” rises to levels close to that of normal rats.

Diabetes can significantly increase the oxidative stress in the body, but eating shell-broken영지버섯 spores for four weeks can significantly reduce the concentration of MDA (malondialdehyde) and ROS (reactive oxygen species) in the blood of diabetic rats. These two values are still higher than those of normal rats, but the two important antioxidant enzymes, GSH-Px (glutathione peroxidase) and SOD (superoxide dismutase) are also higher than those of normal rats, showing that shell-broken영지버섯 spores can effectively enhance the antioxidant capacity of diabetic rats, thereby alleviating excessive oxidative stress.

Further analysis revealed that several genes related to lipid metabolism (Acox1, ACC, Insig-1 and Insig-2), as well as genes related to glycogen synthesis (GS2 and GYG1), have more expression levels than those diabetic rats who did not eat shell-broken영지버섯 spores. 하지만, some genes showed no significant differences, including SREBP-1, Acly, Fas, Fads1, Gpam and Dgat1 involved in lipid metabolism, and PEPCK and G6PC1 involved in carbohydrate metabolism.

All in all, although there is still some distance from “returning to normal”, the shell-broken영지버섯 spore powder has shown its benefits for type 2 diabetes within a month, including lowering blood glucose and blood lipids. From the perspective of gene expression, its mechanism of action may be related to promoting glycogen synthesis, inhibiting gluconeogenesis (inhibiting the conversion of non-carbohydrates into glucose), and regulating the proportion of HDL in cholesterol. As for what active ingredients make the shell-broken영지버섯 spore powder effective, this paper does not specifically elaborate..

[원천] Wang F, 외. Effect of 영지버섯 spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats. Lipids Health Dis. 2015 5월 22;14:49. doi: 10.1186/s12944-015-0045-y.

끝

저자 소개 / 씨. 우팅야오

Wu Tingyao는 이후 직접 Ganoderma 정보를 보고해 왔습니다. 1999. 그녀는 다음의 저자입니다.Ganoderma로 치유 (4월 인민의학출판사에 게재 2017). 

★ 이 글은 저자의 단독 승인 하에 게재되었습니다..

★ 위 작품은 복제할 수 없습니다, 저작자의 허락 없이 발췌하거나 다른 방법으로 사용한 경우.

★ 위 사항을 위반한 경우, 저자는 관련 법적 책임을 추구할 것입니다.

★ 이 기사의 원문은 Wu Tingyao가 중국어로 작성하고 Alfred Liu가 영어로 번역했습니다.. 번역 내용에 차이가 있는 경우 (English) 그리고 원본 (중국인), 원래 중국어가 우선합니다. 독자들이 궁금한 점이 있으면, 원작자에게 연락주세요, 양. 우팅야오.