Ганодерма яркая not only aids in anti-tumor activities but also shows promise in preventing stress-induced hair loss. A May 2024 study published in iScience by Professor Ohsang Kwon and colleagues from Seoul National University College of Medicine, Dermatology Department, indicated that Ганодерма яркая extract can prevent premature aging of hair follicles caused by stress, mitigating the risk of hair thinning or baldness.
When faced with overwhelming stress, the body releases a cascade of hormones to reallocate energy resources and address immediate threats. Corticotropin-releasing hormone (CRH), secreted by the hypothalamus, is a primary stress hormone that not only mobilizes other hormones but also reaches hair follicles, accelerating their aging and impairing hair growth.
Hair growth requires the coordinated effort of various cell types within the hair follicle. Key players include dermal papilla cells (DPCs) that receive and transmit hair growth signals, outer root sheath cells (ORSCs) that surround the hair root and, together with hair follicle stem cells, promote the transition from the resting to the growth phase, and hair matrix cells that are responsible for producing new hair.
Hair follicle structure diagram
Experiment 1: Ганодерма яркая Inhibits Hair Follicle Aging.
In this in vitro study, three types of cells were isolated from scalp tissue donated by five adults. Results showed that when dermal papilla cells (DPCs) and outer root sheath cells (ORSCs) were treated with CRH for 48 hours, there was a significant increase in senescent cells (cells expressing the senescence marker SA-β-Gal). Однако, when Ganoderma lucidum (ГЛ) extract was added simultaneously, the number of senescent cells remained at normal levels.
The experiment results demonstrate that Ганодерма яркая (ГЛ) extract effectively inhibits CRH-induced senescence in hair follicles.
Experiment 2: Ганодерма яркая protects hair follicle vitality.
Results showed that CRH inhibited the differentiation ability of hair papilla (as indicated by decreased alkaline phosphatase, ALP, expression) and reduced the proliferation of hair matrix cells (as indicated by decreased Ki-67 expression). Однако, co-treatment with Ганодерма яркая (ГЛ) extract mitigated these effects (Фигура 2), suggesting that Ганодерма яркая extract enhances hair follicle resistance to stress and preserves hair follicle vitality.
Ганодерма яркая (ГЛ) extract can protect hair follicle vitality under the threat of CRH.
Experiment 3: Ганодерма яркая maintains hair growth vitality.
To further simulate hair growth in vitro, dermal papilla cells were co-cultured with outer root sheath cells to form elongated two-cell assemblages (TCAs). The lengths of TCAs were compared after 5 days of treatment with CRH in the presence or absence of Ганодерма яркая (ГЛ) извлекать. The results demonstrated that GL extract could indeed counteract the inhibitory effect of CRH and maintain the vitality of hair growth.
Ганодерма яркая (ГЛ) extract can alleviate the inhibitory effects of corticotropin-releasing hormone (CRH) on hair growth vitality.
The mechanism by which Ganoderm lucidum protects hair follicles involves the elimination of free radicals and induction of cell apoptosis.
Почему можно Ganoderm lucidum (ГЛ) extract counteract follicular aging induced by stress? According to the analysis of this study, CRH promotes the generation of reactive oxygen species (ROS) free radicals, which in turn activate aging-related genes (p16, p21), and can even increase the activity of molecules associated with “pro-apoptosis” (JNK, c-jun, Erk1/2, and p38). GL can mitigate the impact of corticotropin-releasing hormone(CRH) by scavenging ROS free radicals and inhibiting the activation of pro-apoptotic molecules.
Schematic diagram of the mechanism by which Ганодерма яркая (ГЛ) extract alleviates stress-induced aging of hair follicle cells
The active ingredient of Ganoderma lucidum that protects hair follicles: Ganoderma lucidum triterpenes
This study has revealed the potential of Ганодерма яркая in protecting hair-follicle growth. But what exactly is the Ганодерма яркая with such a function? Further investigation based on the information provided in this report revealed that theГанодерма яркая (ГЛ) extract used in the experiment was an ethyl acetate fraction further extracted from an ethanol extract of Ганодерма яркая плодовые тела, with ganoderic acid A as its marker compound.
The ethanol extract of Ганодерма яркая fruiting bodies is rich in Ганодерма яркая тритерпены. Другими словами, the active ingredient responsible for protecting hair follicles against stress in the aforementioned experiment originated from these triterpenes. Интересно, when Ганодерма яркая triterpenes encounter senescent cancer cells, they eliminate them efficiently, as demonstrated in another study titled “Senolytic Effect of Ганодерма Люсидум Triterpenoids on HCC Cells.”
It’s clear that triterpenes from Ганодерма яркая are not indiscriminate. Вместо, they exhibit selectivity, protecting normal cells while eliminating abnormal ones. The remarkable properties of Ганодерма яркая triterpenes are indeed intriguing.
Примечание: In the figures of this article, * п < 0.05, ** п < 0.01, *** п < 0.001, и **** п < 0.0001 indicate significant differences between the two groups being compared. The smaller the p-value, the greater the significance of the difference.
[Источник] Sunhyoung Lee, и др.. Ганодерма яркая extract attenuates corticotropin-releasing hormone-induced cellular senescence in human hair follicle cells. iScience. 2024; 27(5):109675.
КОНЕЦ
★ This article is exclusively authorized by the author for publication, и его право собственности принадлежит GanoHerb.
★ The above works cannot be reproduced, извлечено или использовано другими способами без разрешения GanoHerb.
★ Those who have been authorized to use the works should use them within the scope of authorization and indicate the source: ГаноХерб.
★ GanoHerb will pursue legal responsibilities against those who violate the above statement.
★ The original manuscript of this article was authored in Chinese by Wu Tingyao and subsequently translated into English by Alfred Liu. In the event of any inconsistencies between the English translation and the original Chinese text, the latter shall take precedence. For any queries, pls reach out to the original author, РС. У Тинъяо.
